University of Evansville

Chemistry

More than 99 percent of recent graduates from the Department of Chemistry are either attending graduate school or working full time in a related field.

Andy Lampkins

Faculty Photo

Specializations

  • Synthetic Organic Chemistry
  • Drug design/discovery
  • Medicinal Chemistry
  • New Reaction Development
  • Community Pharmacy

Degrees

  • Pharm. D. – Butler University
  • Ph.D. – University of Florida

Research Interests

Dr. Andy Lampkins joined the faculty at the University of Evansville in 2013 as the G. Richard and Rita ’59 Eykamp Endowed Chair in Chemistry. Prior to coming to UE, he held positions as a Walther Cancer Institute Postdoctoral Fellow at the University of Notre Dame, and was a faculty member at Samford University. Dr. Lampkins’ research interests span molecular synthesis, new reaction development, and drug design/discovery. Specifically, his group uses organic chemistry as a tool to solve problems in medicine. Current project areas in his laboratories include: 1. the discovery of structurally novel beta-secretase inhibitor prodrugs for the treatment of Alzheimer’s disease, 2. synthesizing biologically-active amino acid-derived natural products using atom-economical multicomponent reactions, and 3. the development of “smart” therapeutics that can target, detect, and treat disease simultaneously.

Selected Publications

  • Worth, A. C.; Needham, C. E.; Franklin, D. B.; Lampkins, A. J. “Facile Synthesis of Lipophilic d-Amino Acid Conjugates from 4-Alkoxy-Dithionaphthoic Acids”, Synth. Commun., 2012, 42, 2694-2706.

  • Souder, J. P.; Evans, Z. M.; Driver, J. A.; Pozzo, E. J.; Lampkins, A. J. “Synthesis of Chiral Iodo-N,O-Acetonide Aminal Scaffolds via an Efficient Cascade Reaction of Amino Acid-Derived Epoxides”, Tetrahedron Lett., 2011, 52, 6908-6910.

  • Smith, B. A.; Akers, W. J.; Leevy, W. M.; Lampkins, A. J.; Xiao, S.; Wolter, W.; Suckow, M. A.; Achilefu, S.; Smith, B. D.”Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces”, J. Am. Chem. Soc. 2010, 132, 67-69.

  • Lampkins, A. J.; O’Neil, E. J.; Smith, B. D. “Bio-orthogonal Phosphatidylserine Conjugates for Delivery and Imaging Applications”, J. Org. Chem. (Featured Article) 2008, 73, 6053-6058.

  • Lampkins, A. J.; Li, Y.; Al-Abbas, A.; Abboud, K. A.; Ghiviriga, I.; Castellano, R. K. “Assessable Consequences of Donor–s–Acceptor Interactions in b-Aminoketones”, Chem. Eur. J. 2008, 14, 1452-1463.

  • Lampkins, A. J.; Abdul-Rahim, O.; Castellano, R. K. “Remote Asymmetric Induction About a Crowded Aromatic Core”, J. Org. Chem. 2006, 71, 5815–5818.

  • Lampkins, A. J.; Abdul-Rahim, O.; Li, H.; Castellano, R. K. “Enhanced Small-Molecule Assembly through Directional Intramolecular Forces”, Org. Lett. 2005, 7, 4471–4474.